Fixing RDAVIDWebService on Yosemite

I was recently trying to install the R/Bioconductor package RDAVIDWebService and I got the error that the URL has changed. Of course i have to run GO enrichments for about 36 Gene Lists and needed and automated way to do this, which means I needed to figure out if I can install the package.

After some wrangling I got the package to run and while a lot of the steps were mentioned by the package maintainer Cristóbal Fresno here, I found that i had to get some issues resolved myself. So I am putting up the steps i went through in case anyone runs into a similar situation. Briefly, all the steps were described in the post by Fresno and i will walk through those steps as i did myself.

One main thing is to register yourself for an account for using DAVID web service

Work around for the new DAVID Web service configuration V 2.0

1) First of all the HTTPS certificate needs Java 8 in order to run.

Previous versions will not run due to prime size. The maximum size that Java accepts is 1024 bits. This is a known issue (see JDK-6521495).

1.1) Check your java version

java -version

If the version is 1.7.XX or earlier then you need to install Java 8.

I  found that I had to install Java and i went the got the Java 1.8 JDK from the Oracle Website. Specifically I downloaded the files from this particular section


and then proceeded to install the apple package.

Installing openssl

2.3) In MAC (tested in Yosemite) the certificate will not work for the present stable openssl version 0.9.8.

2.3.1) Check your openssl version

openssl version

OpenSSL 0.9.8

If it is >= 1.0.2.d then go to step 2.3.3)

2.3.2) Update your openssl, i.e., download, compile and install it

Download the official release from OpenSSL >= 1.0.2.d

tar -xzvf openssl-1.0.2d.tar.gz

cd openssl-1.0.2d

#Compile it with 64 bits support

./Configure darwin64-x86_64-cc
make test
sudo make install

Now you may need to reflect the change in your system if openssl version keeps pointing to the old version.

cd /usr/bin

mv sudo openssl openssl098
sudo ln -s /usr/local/ssl/bin/openssl openssl

Now i tried to do this using homebrew  that is just trying to update using my brew installation. However I ran into a ruby version error see this post.  Luckily i think i had installed brew from github, so one of the solutions there worked for me


However when I did a it pull i got an error regrarding one of the files and I ended up deleting it. See below for the set of commands i used [I have to apologize that i am unable to reconstruct the error messages as I am writing this post after successfully installing the R packages and I had closed my terminal window]


Once openssl was installed I realized that it was installed in


So I ended up making a symlink to the openssl over there as mentioned about

 467 cd /usr/bin/
 468 ls -ltrh openssl
 469 openssl version
 470 sudo mv openssl openssl098zg
 471 sudo ln -s /usr/local/Cellar/openssl/1.0.2d_1/bin/openssl

Now finally we have openssl working.

Adding the CA cert for DAVID worked as the instructions below

2.3.3)  Get DAVID’s certificate and install it into cacerts

Get the certificate:


echo -n | openssl s_client -connect | sed -ne ‘/-BEGIN CERTIFICATE-/,/-END CERTIFICATE-/p’ > ncifcrf.cert

Check if it was properly downloaded:
openssl x509 -in ncifcrf.cert -text

Backup the cacerts file. In my case the 1.8.0_60 jdk version is located in /Library/Java/JavaVirtualMachines/jdk1.8.0_60.jdk/Contents/Home/jre/lib/security/ directory

sudo find / -name cacerts
/Library/Internet Plug-Ins/JavaAppletPlugin.plugin/Contents/Home/lib/security/cacerts

sudo cp /Library/Java/JavaVirtualMachines/jdk1.8.0_60.jdk/Contents/Home/jre/lib/security/cacerts .

sudo cp /Library/Java/JavaVirtualMachines/jdk1.8.0_60.jdk/Contents/Home/jre/lib/security/cacerts
sudo keytool -import -trustcacerts -keystore cacerts -storepass changeit -noprompt -alias david -file ncifcrf.cert
Certificate was added to keystore

The certificate should be added to the keystore. Now, copy the new cacerts version to the original position

sudo cp cacerts /Library/Java/JavaVirtualMachines/jdk1.8.0_60.jdk/Contents/Home/jre/lib/security/cacerts

The only hiccups in updating the R Java configuration were the following

  • I wanted to update the  install. The actually executable was under

however if you to call this in terminal it kept popping up the GUI and i could not use R CMD as i originally planned. The workaround is to cd into the directory

cd /Applications/

and then call R locally which works

sudo R CMD javareconf

Also to reinstall the rJava  package  from source I also had to specify the repo i.e use

 install.packages ("rJava", type="source",repos="")

as there was an issue with the tcl/tk libraries in opening up the pop-up for selecting can mirrors

3) Update Java configuration in R. The output may slightly change from windows, linux or mac.

R CMD javareconf

Java interpreter : /usr/bin/java

Java version     : 1.8.0_60

Java home path   : /usr/lib/jvm/java-8-oracle/jre

Java compiler    : /usr/bin/javac

Java headers gen.: /usr/bin/javah

Java archive tool: /usr/bin/jar

Please check that both Java version and path are appropriate. In addition JNI support should also be available.

4) Check that rJava R library works as supposed to.




.jcall(“java/lang/System”, “S”, “getProperty”, “java.runtime.version”)

[1] “1.8.0_20-b26”

In Mac the rJava that downloads is tied to 1.6 java version. If it is the case, you should install it from the source.

install.packages(‘rJava’, type=’source’)



.jcall(“java/lang/System”, “S”, “getProperty”, “java.runtime.version”)

[1] “1.8.0_20-b26”

And thats it now DAVID works.